Dishman Netherlands offers a number of pharmaceutical products such as Vitamin D analogs and, Vitamin D products which ensures the right concentration of calcium and phosphorus in the blood. Active pharmaceutical ingredients are used for the treatments of such illnesses as Rickets, Osteoporosis and Psoriasis. Besides these products we also offer Cholesterol HP which is used in liposome drug delivery systems.
Ergocalciferol is used to ensure the right concentration of calcium and phosphorus in the blood. It is produced out of ergosterol by performing several chemical reactions. Ergosterol itself is obtained from yeast fed with sugars, a natural vegetable source.
Dihydrotachysterol (DHT-2) is a vitamin D2 analog. The human body converts this material into a product that resembles the molecular structure of calcitriol. Because of this resemblance the mode of action of this product is comparable to calcitriol.
Alfacalcidol is a vitamin D analog. This substance is converted into the active hormone calcitriol by the human body. Alfacalcidol is not naturally occurring in the metabolic systems of humans or animals.
Some drugs have toxic effects on the healthy parts of our body. Encapsulation of these drugs in lipids (liposome) can be a way to deal with this.
The drug is transported to a targeted area inside the lipid body. Upon arrival at the target area the lipid body releases the drug. By using this mechanism the dosage of drug can often be decreased and so are the side effects. The lipids consist of phospholipids and are stabilized with cholesterol. Both substances are present in the human body and will therefore not be attacked by its defence mechanism.